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Laboratorium Biologii Komórki

2021

Kolmus K, Erdenebat P, Szymańska E, Stewig B, Goryca K, Derezinska-Wolek E, Szumera-Cieckiewicz A, Brewinska-Olchowik M, Piwocka K, Prochorec-Sobieszek M, Mikula M, Miaczynska M.

Concurrent depletion of Vps37 proteins evokes ESCRT-I destabilization and profound cellular stress responses.

Porebska N, Pozniaka M, Krzyscik MA, Knapika A, Czyrek A, Kucinska M, Jastrzebski K, Zakrzewska M, Otlewski J, Opalinski L.

Dissecting biological activities of fibroblast growth factor receptors by the coiled-coil-mediated oligomerization of FGF1.

2020

Szymańska E, Nowak P, Kolmus K, Cybulska M, Goryca K, Derezińska-Wołek E, Szumera-Ciećkiewicz A, Brewińska-Olchowik M, Grochowska A, Piwocka K, Prochorec-Sobieszek M, Mikula M, Miączyńska M.

Synthetic lethality between VPS4A and VPS4B triggers an inflammatory response in colorectal cancer.

 Miaczynska M, Munson M.

Membrane Trafficking: Vesicle Formation, Cargo Sorting and Fusion.

Pozniak M, Sokolowska-Wedzina A, Jastrzebski K, Szymczyk J, Porebska N, Krzyscik MA, Zakrzewska M, Miaczynska M, Otlewski J, Opalinski L.

FGFR1 Clustering With Engineered Tetravalent Antibody Improves the Efficiency and Modifies the Mechanism of Receptor Internalization.

Cendrowski J, Kaczmarek M, Mazur M, Kuzmicz-Kowalska K, Jastrzebski K, Brewinska-Olchowik M, Kominek A, Piwocka K, Miaczynska M.

Splicing variation of BMP2K balances abundance of COPII assemblies and autophagic degradation in erythroid cells.

Cendrowski J, Miaczynska M.

Splicing variants of an endocytic regulator, BMP2K, differentially control autophagic degradation in erythroid cells.

Maksymowicz M, Miączyńska M, Banach-Orłowska M.

Clathrin- and dynamin-dependent endocytosis limits canonical NF-κB signaling triggered by lymphotoxin β receptor.

2019

Banach-Orłowska M, Wyszyńska R, Pyrzyńska B, Maksymowicz M, Gołąb J, Miączyńska M.

Cholesterol restricts lymphotoxin β receptor-triggered NF-κB signaling.

2018

Banach-Orłowska M, Jastrzębski K, Cendrowski JMaksymowicz M, Wojciechowska K, Korostyński M, Moreau D, Gruenberg J, Miaczynska M.

The topology of lymphotoxin β receptor accumulated upon endolysosomal dysfunction dictates the NF-κB signaling outcome.

Budick-Harmelin N, Miaczynska M.

Integration of the Endocytic System into the Network of Cellular Functions.

2017

Jastrzębski K, Zdżalik-Bielecka D, Mamińska A, Kalaidzidis Y, Hellberg C, Miaczynska M

Multiple routes of endocytic internalization of PDGFRβ contribute to PDGF-induced STAT3 signaling

Szymanska E, Budick-Harmelin N, Miaczynska M.

Endosomal "sort" of signaling control: The role of ESCRT machinery in regulation of receptor-mediated signaling pathways.

2016

Szymanska E, Skowronek A, Miaczynska M

Impaired dynamin 2 function leads to increased AP-1 transcriptional activity through the JNK/c-Jun pathway

Mamińska A, Bartosik A, Banach-Orłowska M, Pilecka I, Jastrzębski K, Zdżalik-Bielecka D, Castanon I, Poulain M, Neyen C, Wolińska-Nizioł L, Toruń A, Szymańska E, Kowalczyk A, Piwocka K, Simonsen A, Stenmark H, Fürthauer M, González-Gaitán M, Miaczynska M

ESCRT proteins restrict constitutive NF-κB signaling by trafficking cytokine receptors

Song J, Mu Y, Li C, Bergh A, Miaczynska M, Heldin CH, Landström M

APPL proteins promote TGFβ-induced nuclear transport of the TGFβ type I receptor intracellular domain

Cendrowski J, Mamińska A, Miaczynska M

Endocytic regulation of cytokine receptor signaling

Mikula M, Skrzypczak M, Goryca K, Paczkowska K, Ledwon JK, Statkiewicz M, Kulecka M, Grzelak M, Dabrowska M, Kuklinska U, Karczmarski J, Rumienczyk I, Jastrzebski K, Miaczynska M, Ginalski K, Bomsztyk K, Ostrowski J.

Genome-wide co-localization of active EGFR and downstream ERK pathway kinases mirrors mitogen-inducible RNA polymerase 2 genomic occupancy.

Tudek B, Zdżalik-Bielecka D, Tudek A, Kosicki K, Fabisiewicz A, Speina E

Lipid peroxidation in face of DNA damage, DNA repair and other cellular processes

2015

Torun A, Szymańska E, Castanon I, Wolińska-Nizioł L, Bartosik A, Jastrzębski K, Miętkowska M, González-Gaitán M, Miaczynska M

Endocytic adaptor protein Tollip inhibits canonical Wnt signaling

Banach-Orlowska M, Szymanska E, Miaczynska M

APPL1 endocytic adaptor as a fine tuner of Dvl2-induced transcription

Kalaidzidis I, Miaczynska M, Brewińska-Olchowik M, Hupalowska A, Ferguson C, Parton RG, Kalaidzidis Y, Zerial M

APPL endosomes are not obligatory endocytic intermediates but act as stable cargo-sorting compartments

Kolanczyk M, Krawitz P, Hecht J, Hupalowska A, Miaczynska M, Marschner K, Schlack C, Emerich D, Kobus K, Kornak U, Robinson PN, Plecko B, Grangl G, Uhrig S, Mundlos S, Horn D

Missense variant in CCDC22 causes X-linked recessive intellectual disability with features of Ritscher-Schinzel/3C syndrome

2014

Sadowski Ł, Jastrzębski K, Purta E, Hellberg C, Miaczynska M

Labeling of platelet-derived growth factor by reversible biotinylation to visualize its endocytosis by microscopy

2013

Pyrzynska B, Banach-Orlowska M, Teperek-Tkacz M, Miekus K, Drabik G, Majka M, Miaczynska M

Multifunctional protein APPL2 contributes to survival of human glioma cells

Sadowski L, Jastrzębski K, Kalaidzidis Y, Heldin CH, Hellberg C, Miaczynska M

Dynamin Inhibitors Impair Endocytosis and Mitogenic Signaling of PDGF

Miaczynska M

Effects of membrane trafficking on signaling by receptor tyrosine kinases

2012

Hupalowska A, Miaczynska M

The new faces of endocytosis in signaling

Hupalowska A, Pyrzynska B, Miaczynska M

APPL1 regulates basal NF-κB activity by stabilizing NIK

Zerrouqi A, Pyrzynska B, Febbraio M, Brat DJ, Van Meir EG

P14ARF inhibits human glioblastoma-induced angiogenesis by upregulating the expression of TIMP3

Winiarska M, Nowis D, Bil J, Glodkowska-Mrowka E, Muchowicz A, Wanczyk M, Bojarczuk K, Dwojak M, Firczuk M, Wilczek E, Wachowska M, Roszczenko K, Miaczynska M, Chlebowska J, Basak GW, Golab J

Prenyltransferases Regulate CD20 Protein Levels and Influence Anti-CD20 Monoclonal Antibody-mediated Activation of Complement-dependent Cytotoxicity

2011

Urbanska A, Sadowski L, Kalaidzidis Y, Miaczynska M

Biochemical characterization of APPL endosomes: the role of annexin A2 in APPL membrane recruitment

Pilecka I, Sadowski L, Kalaidzidis Y, Miaczynska M

Recruitment of APPL1 to ubiquitin-rich aggresomes in response to proteasomal impairment

2010

Miaczynska M, Bar-Sagi D

Signaling endosomes: seeing is believing

2009

Pyrzynska B, Pilecka I, Miaczynska M

Endocytic proteins in the regulation of nuclear signaling, transcription and tumorigenesis

Rashid S, Pilecka I, Torun A, Olchowik M, Bielinska B, Miaczynska M

Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription.

Sadowski L, Pilecka I, Miaczynska M

Signaling from endosomes: location makes a difference.

Banach-Orlowska M, Pilecka I, Torun A, Pyrzynska B, Miaczynska M

Functional characterization of the interactions between endosomal adaptor protein APPL1 and the NuRD co-repressor complex

Olchowik M, Miaczyńska M

[Effectors of GTPase Rab5 in endocytosis and signal transduction]

Ohya T, Miaczynska M, Coskun U, Lommer B, Runge A, Drechsel D, Kalaidzidis Y, Zerial M

Reconstitution of Rab- and SNARE-dependent membrane fusion by synthetic endosomes.

2008

Miaczynska M, Stenmark H

Mechanisms and functions of endocytosis.

Kubiak JZ, Ciemerych MA, Hupalowska A, Sikora-Polaczek M, Polanski Z

On the transition from the meiotic to mitotic cell cycle during early mouse development.

2007

Pilecka I, Banach-Orlowska M, Miaczynska M

Nuclear functions of endocytic proteins